OBJECTIVES:   The Human Papillomavirus (HPV) infection is the most common sexually transmitted disease in the United States. HPV infected males also put their female partners at increased risk of cervical cancer. Recently a HPV vaccine was approved for use in males aged 9-26 years. The purpose of this study was to assess awareness regarding HPV and the vaccine amongst a cohort of male university students.  Further, we evaluated their attitude towards the HPV vaccine and its relationship with awareness.  METHODS: A self-administered anonymous survey was administered to a sample of male university students aged 18-26 years. Patient characteristics measured included education, race, major, marital/relationship status and insurance status. Awareness regarding HPV and the vaccine, and attitude towards willingness to get vaccinated, perceived risks of being infected with HPV, and benefits of the vaccine were measured using a 5 point Likert scale. Coded data were analyzed by conducting descriptive and correlation analysis using SAS 9.2. RESULTS: A total of 203 completed surveys were obtained. Mean (±SD) age of participants was 21.56 (±2.44) years. Mean awareness scores were high for HPV (3.89 ± 1.34) and HPV vaccine (3.55 ± 1.30). Mean attitude scores were somewhat mixed for willingness to get vaccinated (2.89 ± 1.10), benefit of vaccination (3.18 ± 1.04), and at risk of getting HPV (3.15 ±1.21). There was no significant co-relationship between attitude and awareness variables. Willingness to get vaccinated was negatively correlated with perceived risk (r=0.15, p <0.05) and vaccination benefit (r=0.34, p<0.05).  CONCLUSIONS: Despite awareness regarding HPV and HPV vaccine a large proportion of the cohort was not willing to get vaccinated.  This may be due to the perception of not being at risk of getting infected and not having a clear understanding of the benefits of vaccination.