OBJECTIVES: To understand how patients perceived the relevance and ease of understanding of the questions included in SAT questionnaire to reflect key patient-reported outcomes of NP treatments and to provide recommendations modifications based on patient clinician interviews. METHODS: Semi-structured interviews were conducted with clinicians and NP patients to inform on treatment attributes and pain impacts. Patients were debriefed on the SAT, a 5-item scale evaluating pain, activity level, quality of life (QL) and satisfaction with treatment (recommend treatment and undergo treatment again). SAT has a recall period reflecting back to initiation of treatment. The qualitative analysis software ATLAS.ti 5.0 was used to analyze patient transcripts. Changes to SAT underwent debriefings. RESULTS: Three NP clinicians and 44 patients (20 painful diabetic neuropathy, 16 HIV-associated neuropathy and 8 post herpetic neuralgia) with a mean age of 60.3(12.3) years and an even gender distribution were interviewed. Patient treatment experience ranged from anticonvulsants (73%), antidepressants (34%), opioids (25%), to topical medications (41%). Pain descriptors and treatment attributes were similar across the three NP groups. Pain relief was judged the most important treatment attribute, followed by ability to do activities. Sleep improvement was another important attribute. Activity limitations and QL were perceived as too broad and unspecific, and were split into 3 concepts each (self care, daily and physical activities; sleep, emotions, and social function). A 7-day recall period was introduced. The item stem and response options were made consistent, and a baseline and follow-up questionnaires were developed (except for the satisfaction items) to enable monitoring onset of treatment benefit and change over time.  CONCLUSIONS: The content validity of the revised SAT was improved by the qualitative research, and NP treatment benefits are reflected in a more consistent fashion by the changes. Baseline and follow-up versions make assessments of change over time possible.