OBJECTIVES: Human Immunodeficiency Virus (HIV) has become a chronic manageable disease after the advent of combination antiretroviral therapy (ART). Since launching of ART, the numbers of patients enrolled in to ART are increasing in developing countries like India. In this study we aim to analyze clinical and immunological outcomes of ART in a community care hospital.  METHODS: A retrospective cohort study was conducted by including 800 ART naive HIV infected adult patients initiated on ART. All patients survived in ART centre at Mysore, India for 12 months from January 2013 to January 2014 were included. Parameters like weight, hemoglobin, WHO clinical stage and CD4 count were collected from medical records before initiation and after completion of 12 months ART. Outcomes of ART were analyzed by paired T- test using SPSS version 21. RESULTS: A statistically significant improvement was observed for weight [53.9 (11.9) to 58.2 (32.6) kg; P = 0.002] and CD4 count [206.6 (177.4) to 331.1 (220.5); P = 0.001] at the end of 12 months of ART treatment. Whereas, marginal improvement in hemoglobin [11.94 (4.3) to 11.98 (5.7) g%; P = 0.91] was observed, though it was not statistically significant. Also observed a significant increase in percentage of patients in WHO clinical stage I (64-82%) and decrease in number of patients in stages II (13-14%), III (5-2%) and IV (18-12%). CONCLUSIONS: The improvement in weight and CD4 count are indirect parameters of >95% medication adherence and of sustained viral suppression. The optimal outcome would have been all patients in WHO clinical stage I or II and none in III and IV, but in this study 2% and 12% of patients continued to be in stage III and IV respectively. This may be due to development of opportunistic infections such as tuberculosis which is endemic in India.