OBJECTIVES The number of seniors in Europe is increasing. The aim of our research study was to determine quality of life in the long term hospitalized seniors with psychiatric diseases and to determine to what extent the age and education affects the quality of life. METHODS Two standardized questionnaires - WHOQOL-BREF (World Health Organization Quality of Life Assessment-Brief) and WHOQOL-OLD (World Health Organization Quality of Life Assessment-Old) were used in the study. The research sample consisted of 100 patients hospitalized in geriatric psychiatric department of a Woman's Psychiatric Hospital in Kroměříž. Patients were from 65 to 95 years old. Duration of hospitalization was from 2 to 12 months. Data were collected was in October 2012 - February 2013. RESULTS Average score WHO-QOL BREF was lower than of the population norms. Satisfaction with health was lower than the assessment of quality of life. Comparing the results to respondents 79 years old and over 80 years old it has been found lower scores in all domains of quality of life by younger patients. Worsening of physical health and quality of social relations were patients with lower level of education. Other domains were worse evaluated by patients with higher level of education. Assessment domains WHOQOL OLD values were lower than of population norms. Very low score, regardless of age and education, appeared in ratings independence. CONCLUSIONS Long-term hospitalization is reflected in the perception of quality of life, particularly in the physical domain and the feeling of dependence. Chronic health problems, social isolation, reduction in the activity disturb seniors wellbeing and reduce subjective assessment of quality of life. The effort to engage of hospitalized seniors in society and leisure activities can increase the quality of their life. Early diagnosis and treatment reduce the price of treatment and length of hospitalization