OBJECTIVES: The aging of the population and the increase of chronic disease patients represent the current medical and socio-economic challenges. In 2008, facing considerable increase of medicines cost in nursing homes (NH) in the canton of Vaud (Switzerland), professionals around the resident were invited to develop a collaborative pharmacy practice model derived from the successful experimentation in the canton of Fribourg. The intervention called Quality Circle in NH is an evidence-based program with a direct influence on the prescriber, that promotes team based care and clinical guidelines. The model has showed sustainable evidence of the cost containment of medicines without affecting the quality of care. The objective of this study was to assess the first results of economic impact of the program in NH engaged between 2009 and 2012. METHODS: Individual data by NH resident was derived from community pharmacists’ invoice and from resident admission data. The evolution of the daily mean drug cost per resident was compared to the evolution of the daily mean drug cost of the population over 65 years old in primary care from cantonal pharmacy invoice (Swiss Health Observatory, OBSAN).  RESULTS: Between 2009 and 2012, 13 NH were entered into the program (601/6’492 beds, 9.3%), between 9 and 11 NH were monitored. In 2012, the mean age of residents was 88 (SD 7.3) years old; 78% were women. From 2009 to 2012 the daily mean drug cost per resident of the program decreased to 10.3% from 6.8 to 6.1 EUR, representing a clear reduction compared to cantonal invoice that record an increase of 0.59%.  CONCLUSIONS: The monitoring of the program shows first positive results due to the reduction of drug costs. Nevertheless, this model has an operating cost. The next step will be to determine the break even point of the intervention.