OBJECTIVES To compare the health utility of Acute Coronary Syndrome (ACS) patients from an Asian population at baseline admission and 12 months post-ACS. Secondary objectives were to investigate the factors that affect health utility and the impact of using local versus UK tariffs in the analysis. METHODS Primary data was obtained from ACS patients who were admitted to a tertiary-care, general hospital in Malaysia and agreed to participate in the study. The quality of life (QOL) of ACS patients was elicited using validated language versions of the EQ-5D (three severity level) patient reported outcome instrument. QOL data was collected at baseline during initial admission for ACS and at 12-months post-admission. Patient demographic and clinical data were extracted from medical records. Health utility scores were calculated using EQ-5D utility tariffs from Malaysia and the UK population tariff.   RESULTS A total of CONCLUSIONS This study investigates several factors that may impact the QOL outcomes of Malaysian ACS patients. It also found significant differences in utility values calculated by Malaysian and UK tariffs, which indicate that the use of local tariffs is more appropriate.