OBJECTIVES There are few studies in Spain about outcomes at 1-year in terms of health-related quality of life (HRQoL) in patients hospitalized by heart failure (HF). The main objective of the present study was to evaluate changes in HRQoL from baseline to 1-year post discharge in patients with HF through two questionnaires, SF-12 and Minnesota Living with Heart Failure questionnaire (MLHFQ) METHODS This has been a prospective study with 502 patients admitted by HF in Basque Country (Spain). Patients completed questionnaires during their hospitalization and at 1-year. The MLHFQ is a specific instrument which has 21 items with an overall scale, physical (8 items) and emotional (5 items) subscales. MLHFQ items are scoring from 0 (best) to 5 (worst). Total score ranges from 0 to 105, physical domain from 0 to 40 and emotional from 0 to 25. SF-12 has two dimensions, Physical Summary Score (PCS) and Mental Summary Score (MSC) which scores range from 0 (worst) to 100 (best). We have used general linear model to study gains in each dimension adjusted by baseline score, age, gender and hospital readmissions in the previous 6 months. RESULTS Mean age was 76.7 (SD=10.4), there were a 56.1% of men and 20.3% of readmissions in the previous six months.  Regarding both questionnaires and dimensions, baseline status influence in gains, the worse the baseline the more the gains. Likewise men have greater gains and patients readmitted lower in all domains. Age has an influence in MLHFQ physical domain and PCS. CONCLUSIONS Adjusted by baseline score and readmissions, men have greater improvements in all domains of MLHFQ and SF-12. On the other hand, the younger the patients the higher the improvement is, in physical domains however age does not have any influence in psychological domains.