OBJECTIVES: To assess health-related quality of life (HRQOL) and subjective happiness of men with lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH/LUTS). METHODS: In 2014 a multicenter cross-sectional questionnaire survey was conducted in Hungary. Inclusion criteria were diagnosis of BPH/LUTS at least 12 months before the study and patient had never been undergone any prostate surgery. HRQOL was assessed indirectly by the EQ-5D and visual analogue scale (EQ VAS) and directly by matching indifference time trade-off (TTO) where patients’ subjective life expectancy was applied as time frame. Subjective happiness was measured on a 10-cm-long visual analogue scale. RESULTS: In total 64 men completed the questionnaire, mean age and disease duration were 70.8±8.8 years and 6.9±6.5 years, respectively. At the time of the survey, 75% of the patients received alpha-blockers (AB), 11% were treated by 5-alpha-reductase inhibitors (5ARI), and 11% by combination therapy (AB+5ARI). Median EQ-5D, EQ VAS, TTO and happiness scores were 0.85, 70, 0.73 and 6.5, respectively. Utilities assessed by EQ-5D were found significantly higher compared to those elicited by TTO (p<0.001). Mean utilities decreased with clinical severity measured with EQ-5D (mild: 0.90±0.1, moderate to severe: 0.79±0.2, p=0.046) whereas increased when assessed with TTO (mild: 0.46±0.3, moderate to severe: 0.63±0.3, p=0.336). Patients with moderate to severe disease reported significantly lower happiness scores than those with mild disease (5.85±2.2 and 7.02±2.3, p=0.044). Subjective happiness correlated moderately with EQ VAS (r_s=0.64, p<0.001) but only weakly with EQ-5D (r_s=0.28, p=0.029). CONCLUSIONS: BPH/LUTS patients experience notable reduction in their HRQOL and subjective happiness measured by any of the applied outcome measures. Utilities for BPH/LUTS ranged from 0.46 to 0.90 depending on clinical severity and assessment method. Considerable discrepancy was found between utilities elicited by EQ-5D and TTO that raises concerns about which method is feasible to use for utility evaluation in BPH/LUTS.