OBJECTIVES To describe the characteristics and burden of caregivers and patients affected by relapsing-remitting multiple sclerosis (RRMS), and to describe their satisfaction with treatment.  METHODS Multicenter, observational, cross-sectional study in RRMS patients≥18 years(y), treated for ≥1y. Burden was assessed with the Zarit Burden Interview. Other measures were: Center for Epidemiologic Studies Depression Scale, short form (CESD-7); and treatment satisfaction of caregivers (ad-hoc questionnaire) and patients (Treatment Satisfaction Questionnaire for Medication (TSQM)).  RESULTS We included 180 patients (mean (SD) age 41(11)y, 66% female) and caregivers (47(12)y, 56% female, 67% economically active). Most caregivers were relatives (59% partner;25% parent;9% brother or sister) and lived with the patient (86%);37% helped with the medication. Median(Q1,Q3) time since diagnosis was 7(4,10)y and between diagnosis and first treatment, 0.3(0.2,1.3)y. Most patients received monotherapy with interferon beta(51%), glatiramer acetate(20%), natalizumab(14%) or fingolimod(7%); 15.6% received ≥2 drugs. Median EDSS was 2.5(1,4). According to the Zarit Interview, 19% of caregivers had some degree of burden (median:10(7,15)). Factors associated with burden were: EDSS (mean(SD) in caregivers with burden vs without burden, respectively:4.0(2.1) vs 2.6(1.9),p<0.0005), years of caregiving (mean:4.0(4.5) vs 2.7(4.5)y,p=0.005), daily hours dedicated to patient (10.8(12.1) vs 5.8(4.6) hours,p=0.038), and >1 drug (39% of burden when patients take≥2 drugs vs 16% with monotherapy,p=0.004). Other caregiver’s characteristics (age, gender, professional activity, relationship with patient or cohabitation) were not significantly associated. 28.2% of caregivers had depression (CESD-7≥15). Both patients (90% satisfied or very satisfied according to the TSQM) and caregivers (mean of 7.6(2.3) on a scale from 0-10 [maximum satisfaction]) were quite satisfied with treatment. CONCLUSIONS In the RRMS population with moderate disability, around 2 in 10 caregivers have some degree of burden, and 1 in 4 suffer depression. The burden increases proportionately with disease severity and number of medications administered. Overall, patients and caregivers are satisfied with treatment.