OBJECTIVES The study aimed to (i) evaluate the effectiveness of a multidisciplinary home-based medication review (HBMR) program in reducing hospital admissions and (ii) determine the prevalence of drug-related problems (DRP) in older adult Singaporeans. METHODS A retrospective observational study was conducted at an academic medical centre in Singapore. Patients referred to the HBMR program between March 2011 and December 2012 were included. Home visits were conducted by a team comprising a pharmacist and care coordinators. Frequency of hospital admissions was determined 6 months before and after HBMR. DRP identified were categorised and their outcomes (resolved/unresolved) recorded by the pharmacist. Summary statistics were used to report patient characteristics and prevalence of DRP. Incidence of hospital admissions was compared using Poisson regression, while paired t-test was used to compare associated costs (in Singapore dollars) and length of stay (LOS) before and after HBMR. RESULTS The analysis included 107 patients with mean (SD) age of 75.6 (7.6) years. There were 52 (48.6%) males, and 89 (83.2%) were Chinese. The implementation of the HBMR program resulted in a 41% reduction in risk for hospital admissions (IRR: 0.59; 95% CI: 0.47 – 0.73, p< 0.001). Mean (SD) costs of hospital admissions reduced from $16,957.77 ($16,118.35) before HBMR to $7,488.76 ($12,773.40) after HBMR (p< 0.001). In a subgroup analysis of 62 patients who had hospital admissions before and after HBMR, mean (SD) LOS decreased from 26.5 (22.4) days to 17.6 (17.8) days (p= 0.010). The team identified 525 DRP from 1,353 medications reviewed. Of these, 34 (6.7%) and 174 (34.1%) DRPs were resolved with and without physician involvement respectively. The most common DRP identified were failure to receive drug (n= 163, 31.0%) and untreated indication (n= 140, 26.7%). CONCLUSIONS The multidisciplinary HBMR program was effective in reducing hospital admissions in older adult Singaporeans with multiple DRP.