OBJECTIVES: The rising cost of treatment of peripheral arterial disease and the growing incidence of this disease led to economic analysis of arterial disease. With the increasing price of modern instrumentation, it is appropriate to evaluate not only clinical efficiency, but also intervention economics. This study aims to create a recommendation for choosing the most effective treatment based on both economic data and clinical outputs of the disabled superficial femoral artery.  METHODS: The methods chosen were reviewed from clinical outputs for treatment effectiveness, multiple-criteria decision-making for the synthesis of treatment effects, analysis of costs at the selected interventions and cost-effectiveness analysis.  RESULTS: The four clinical outputs used in the study as a criterion by the research of the clinical studies were primary patency, technical success, patient survival and limb salvage at the year of operation. The weights of each criterion, and the preferences of the interventions were counted. The sequence of interventions was set by the AHP method: PTA (35.6%), PTA/S (33.9%) and bypass (30.6%) and method of weighted sum: PTA/S (56%), bypass (55%) and PTA (42%). From the view of both health insurance payer and healthcare provider, where the direct medical expenditures were included, the order of intervention was the same: PTA, bypass and PTA/S. The cost-effectiveness was calculated for both, and the PTA intervention achieved the best results. Incremental expenditures by unit of effect was calculated for each effect: ICER or the domination of one intervention over another was set. Ratio of the ICER was generally higher for PTA/S compared to bypass. In the sensitive analysis was determined the influence of the direct medical expenditures on the final outputs.  CONCLUSIONS: The treatment of disabled superficial femoral artery was compared from chosen clinical outputs, economic expenditures and cost-effectiveness. On this basis, the recommendation was set for choosing the most effective treatment.