OBJECTIVES: Coffee contains over 1,000 distinct molecular compounds and is one of the most widely consumed beverages worldwide. Epidemiologic studies have shown an inverse relationship between coffee consumption and all-cause mortality. This analysis aims to assess the cost-effectiveness of coffee from a blended German consumer and payer perspective. METHODS: An existing decision-analytic model was adapted with German data. A cohort life-table analysis was developed to model life-years (LYs) of German coffee consumers vs. non-consumers over a lifetime horizon. Age- and gender-specific mortality rates were used to model survival outcomes. Relative risks of death by average coffee intake (cups/day) were obtained from a recent large, prospective cohort study. Cost were considered for cost per cup (home prepared and from a national sample of low and high-cost vendors) and for healthcare. Incremental analyses were conducted by cost, sex, and level of daily coffee consumption. Deterministic and probabilistic sensitivity analysis was performed. RESULTS: Coffee increased undiscounted LYs in 1, 2-3, 4-5, and 6+ cup/day male (0.65, 1.10, 1.33 and 1.10) and female (0.45, 1.21, 1.51, 1.41) consumers, respectively, versus non-consumers. ICERs per undiscounted LY gained were € 3,938/ € 7,047/ € 16,271 for males and € 5,514/ € 5,066/ € 13,537 for females, respectively, for 1, 2-3, and 4-5 cups/day consumption of home-prepared coffee; ≥6 cups/day was strictly dominated. Consumption of 4-5 cups per day purchased from high-cost vendors was not cost-effective (male: € 168,780/ female: € 135,636). Results were consistent throughout the sensitivity analyses, whereas coffee effectiveness in preventing death and coffee acquisition cost has the largest impact on ICERs.  CONCLUSIONS: In this analysis, coffee consumption was associated with increased LYs and was shown to be potentially cost-effective, especially if home-prepared or purchased from low-cost vendors. Given the observational nature of the study data, further research is warranted to validate these findings.