OBJECTIVES Studies have shown that irritable bowel syndrome (IBS) and its subtype with constipation (IBS-C) are associated with poorer HRQoL, decreased work productivity and increased healthcare utilization.  However, no studies have compared the burden of IBS-C to similar chronic conditions. Objective was to evaluate burden of IBS-C compared with no functional gastrointestinal disorders (non-FGID), asthma, migraine, and rheumatoid arthritis (RA), on HRQoL, work productivity and healthcare utilization. METHODS Data come from the 2011 National Health and Wellness Survey (nationally representative sample of adults including the US, UK and France), which includes health-related topics such as HRQoL (SF-12 Health Survey), work productivity (Work Productivity and Activity Impairment) and healthcare utilization (6-month ER visits and hospitalizations).  Comparisons in each of these health-related topics were made between respondents with IBS-C versus non-FGID, asthma, migraine, and RA. Comparisons controlled for age and gender. RESULTS Prevalence of IBS-C was 0.67%, 1.03%, and 0.91% in the US, UK, and France, respectively.  Most respondents were female (>65%) and mean age ranged from 47.7 to 49.8 years.   In each country, mean SF-12 physical (PCS) and mental (MCS) summary scores were statistically (p<0.001) and clinically meaningfully (>= 2.5) lower than the non-FGID group.  With few exceptions, PCS and MCS scores of IBS-C were significantly (p<0.05) lower than scores for asthma, migraine, and RA.  In each country, IBS-C reported significantly (p<0.001) greater absenteeism and worse presenteeism and greater overall work productivity loss and daily activity impairment than non-FGID, and with few exceptions, worse than asthma, migraine, and RA. Lastly, in each country the number of ER and hospital visits was significantly higher (p<0.01) for IBS-C compared to non-FGID and, with few exceptions, higher than asthma, migraine, and RA. CONCLUSIONS In the three countries respondents with IBS -C showed significant and clinically meaningful deficits in HRQoL and work productivity and elevated healthcare utilization compared with other chronic conditions.