OBJECTIVES: To study possible associations and assess the impact of socio-demographic, quality-of-life and coping factors on the severity of Crohn’s disease patients in Israel. METHODS: Consecutive Crohn’s disease patients undergoing clinical follow-up at the Inflammatory Bowel Diseases Clinic completed the following questionnaires: SF-36 quality-of-life, Ways of Coping, and socio-demographic details. Crohn’s disease severity was measured by Harvey-Bradshaw Index (HBI) expanded to include pharmaceutical and surgical therapies as well as medical and surgical hospitalization information. Based on these data, a multifactorial model was built using multivariate linear regression. RESULTS: There were altogether 192 patients: 81 (42.2%) men (age 36.8 ± 14.5 years, disease duration 11.4 ± 8.6 years, education 13.7 ± 2.7 years, HBI 7.6 ± 4.9) and 111 (57.8%) women (age 41.4 ± 15.6*, duration 14.0 ± 9.3*, education 14.2 ± 2.8, HBI 8.4 ± 4.8; *p < 0.05 vs. men). The multifactorial model showed the following significant predictors of disease severity: age (beta = −0.250, p = 0.006), number of children (beta = 0.245, p = 0.008), SF-36 General Health score (beta = −0. 378, p < 0.01), coping/sense of humor (beta = 0.209, p = 0.011), and coping/acceptance (beta = −0.183, p = 0.024). The model accounted for 29% of explained variance, with Adjusted R = 0.26.  Gender, education and socio-economic status were not predictors of disease severity.  CONCLUSIONS:  All of the indicated factors (age, family size, coping skills) had a significant effect on the severity of Crohn’s disease. In addition to prescribing medications, physicians should pay special attention to these factors as part of an overall management plan for their Crohn’s disease patients.