OBJECTIVES: Primary: To describe the use of anti-cancer treatments in elderly patients (≥75 years of age) at the Davidoff Center between 2006 and 2013. Secondary: To investigate the correlations between anti-cancer treatments and socio-demographic- and cancer-related parameters.   METHODS: The analysis included all elderly (≥75 years) cancer patients treated at the Institute of Oncology, Davidoff Center between 2006 and 2013. The analysis included Israeli residents (i.e., “medical tourists” were excluded). Patients who were treated elsewhere and had a single consultation appointment at the Davidoff Center were also excluded from the analysis. The following parameters were assessed: demographic variables, cancer diagnosis, chemotherapy and radiation treatments received, clinic visits, hospitalizations, and the utilization of other health-related services.  RESULTS: Out of 21,009 new patients treated at the Davidoff Center between 2006 and 2013, 6,553 patients (31%) were elderly. Of these patients, 31% received chemotherapy, 35.5% radiotherapy, and 10% both. The proportions of elderly patients receiving chemotherapy, radiation therapy, or both, remained stable throughout the study period. The most common indications for which elderly patients received chemotherapy included gastrointestinal (39%), lung (15%), breast (12%), and head and neck (9%) cancers. Overall, 17% of the elderly patients received >2 lines of chemotherapy protocols; a similar rate (16%) was observed in the subgroup of patients ≥85 years of age.  CONCLUSIONS: Approximately 30% of the cancer population treated in a large tertiary cancer center were elderly patients (≥75 years of age). The findings of this study may promote a discussion regarding medical resources, staff training, and planning a designated evaluation for geriatric cancer patients that should include special consideration to the patients’ comprehensive functioning.