OBJECTIVES: To estimate the IC for adult women with AD in the United States in 2006. METHODS: Females > 17 years who reported AD were selected. A control group was created using propensity score matching.The components of indirect costs were annual national cost of missed work days for employed individuals, annual national cost of other bed days for unemployed individuals, and the present value of future productivity due to premature deaths. To calculate the number of missed work days attributable to AD, the unadjusted mean number of missed work days and other bed days for those without AD was multiplied by the regression coefficient for AD from the multivariate regression minus the unadjusted mean number of missed work days and other bed days for those without AD.  Using the number days attributable to AD and the MEPS sample weights for each individual, the total cost of missed work days and other bed days attributable to AD in the United States was estimated. Mortality costs were calculated as the present value of future productivity due to premature deaths. The total amount of indirect costs was estimated by adding the total from morbidity estimate to the total from the mortality estimate. RESULTS: The morbidity costs was $8.13 billion and mortality costs was $0.46 billion. CONCLUSIONS: Morbidity costs due to lost productivity were the major costs of IC and indicate a significant financial burden that can be reduced by disease management programs.