OBJECTIVES: Average adherence to therapy in patients with diabetes is only 67.5%. This study aims to evaluate the impact of a pharmacist-based diabetes management program on improving medication adherence among diabetic patients. METHODS:   Data collected during a collaborative program in which trained pharmacists provided diabetes management including medication, education and diet and lifestyle modification counseling to diabetic patients was obtained. Medications dispensed before (in 2007) and during (in 2008) the intervention was recorded for the patients receiving the intervention and controls (matched on age ±5 years, HbA1C ±0.1%, gender, and baseline cholesterol levels) as part of this retrospective, longitudinal study. Patients with two or more visits at the participating pharmacies were included in the study. Medication Possession Ratios (MPRs) were calculated for every patient. Analysis involving descriptive statistics and t-tests were performed using SAS version 9.2. RESULTS: A total of 135 cases and 243 controls were included in the study of which 53.3% (n=72) and 50.78% (n=122) were females, respectively. The mean age (SD) of cases and controls was similar 48.6 (11.4) and 47.4 (13.1) years, respectively. The mean MPR(SD) of cases improved from 3.41(3.7) in 2007 to 5.12(10.7) in 2008 (p=0.0902). The MPR(SD) for controls, reduced from 2.96(2.9) in 2007 to 2.16(6.8) in 2008. When the changes in MPR(SD) of every individual were compared cases showed greater change of 1.75(1.4) on an average as compared to 0.015(1.8) for controls(p=0.0907). Although not significant (p=0.083), the percentage of cases that were non-adherent reduced by around 50% from 8.9% in 2007 to 4.4% in 2008. CONCLUSIONS: Adherence to medication in diabetic patients may be improved thorough a planned pharmacists-based disease management program. Further, longitudinal data may be needed to conclusively indicate the impact of pharmacists based intervention.