OBJECTIVES: This study assessed whether health-related quality of life (HRQoL) differed between respondents diagnosed with both diurnal and nocturnal gastroesophageal reflux disease (GERD) and those diagnosed with either type alone, or non-diagnosed respondents. METHODS: Data were analyzed from Kantar Health’s 2010 National Health and Wellness Survey, a nationally representative dataset of US adults (collected over three waves, January 7 to August 13).  Outcome variables were SF-12v2 mental and physical component summary (MCS and PCS) and SF6D health utilities (measuring health status) scores.  Lower scores indicate worse outcomes.  Analyses of covariance (ANCOVAs) predicted MCS, PCS, and SF6D from the four GERD groups and a range of covariates. RESULTS: There were 75,000 respondents: non-GERD (n=68,593), diurnal (n=710), nocturnal (n=1,493), and diurnal-and-nocturnal GERD (n=4,204).  Estimated means adjusted for the following covariates (and others) at levels shown: gender (48% female); age (48.2); African American (11%); Hispanic (6%); BMI: overweight (32%) and obese (33%); Charlson comorbidity index, excluding ulcers (.397); and taking prescription for GERD (6%).  All groups exhibited significantly higher MCS scores than the diurnal-and-nocturnal GERD Group (MNon-GERD = 48.6, SE = 0.043; MDiurnal = 47.5, SE = 0.426; MNocturnal = 47.4, SE = 0.314; MDiurnal&Nocturnal = 45.0, SE = 0.249); higher PCS scores (MNon-GERD = 48.5, SE = 0.038; MDiurnal = 47.6, SE = 0.377; MNocturnal = 47.4, SE = 0.278; MDiurnal&Nocturnal = 45.6, SE = 0.220); and higher SF6D scores (MNon-GERD = 0.752, SE = 0.001; MDiurnal = 0.727, SE = 0.005; MNocturnal = 0.729, SE = 0.004; MDiurnal&Nocturnal = 0.695, SE = .003), all ps <0.001. CONCLUSIONS: Based on this analysis, respondents with both diurnal-and-nocturnal GERD suffer poorer HRQoL than those with no GERD, or only diurnal or nocturnal GERD.  This suggests an unmet need to improve medical care especially for those who have both diurnal and nocturnal GERD.