OBJECTIVES: Spasticity is a common condition among patients with progressive and/or relapsing forms of multiple sclerosis (MS). Current therapies seem to partially control spasticity symptoms, and patients often receive multiple treatments or switch to new treatments to achieve a better control. The objective of this analysis was to assess the current usage of spasticity drugs and relative patterns of utilization among patients with MS, through administrative database analysis. METHODS: Using DENALI datawarehouse, we detected MS patients who, during the period January 2000 – December 2009, had at least one disease modifying agent (DMA)prescription  Then the usage of drugs commonly used in spasticity (muscle relaxant drugs, baclofen, tizanidine, clonidine, dantrolene) was evaluated in this cohort of patients, in terms of number of subjects receiving at least one prescription, and number of DDD (defined daily doses) per patient per year.  RESULTS: From 2000 to 2009, the annual number of patients with MS, receiving DMA treatment raised from 10,746 to 12,594. Concomitantly, the annual number of patients receiving at least one muscle relaxant prescription raised from 5.87% (n=631) to 9.42% (n=1,186). The most prescribed drug was baclofen  with few patients receiving other drugs commonly indicated in spasticity (dantrolene, tizanidine and clonidine). A relevant number of patients using muscle relaxants also received other drugs for the central nervous system, although its usage achieved a peak in 2005 (8% of MS patients). The analysis of DDD per patient/year suggested that the usage of muscle relaxant might be almost chronic in these patients (in 2009, 303 DDD per patients per year). CONCLUSIONS: Only 10% of patients with MS currently receive active pharmacological treatment, although this condition seems affecting more than 20% of MS patients in Europe. Also, there are not relevant alternatives or second line options to baclofen, which is the most commonly prescribed drug in this condition.