OBJECTIVES: Calcium channel blockers are drugs of first choice in the treatment of hypertension. The aim of this study was to analyze the consumption of calcium channel blockers in Serbia in the period from 2007 to 2011 year. METHODS: The data about the use of drugs were taken from the Agency for Drugs and Medical Devices of the Serbia. RESULTS: The most frequently used drug from this group with mainly vascular effects was amlodipine. During this observed five years the consumption of amlodipine is in steadily increased. In 2007. it was 21.25DDD/1000 inh/day, at the end of 2011. year the consumption was  72.97DDD/1000 inh/day. On the second place in drug consumption in the same group of drugs was nifedipine. Contrary to amlodipine, nifedipine recorded a decline in consumption. From the calcium channel blockers with direct cardiac effects the most frequently used drugs were verapamil and diltiazem. The consumption of  verapamil in the observed years was  uneven. At the and of 2011. consumption of  this drug was reduced by 50%. The consumption of diltiazem in  observed  five  years  is in constantly decreasing. CONCLUSIONS: In Serbia, in the observed period the consumption of calcium channel blockers been uneven. In 2010 and 2011 the consumption of calcium channel blockers marks a positive  trend. This research was supported by Provincial Secretariat for Science and Technological Development, Autonomous Province of Vojvodina project No 114-451-2458/2011 and by Ministry of Science, Republic of Serbia, project no 41012.