THE BENEFIT-HARM FRONTIER OF DIFFERENT PRIMARY SCREENING STRATEGIES FOR CERVICAL CANCER IN GERMANY

Author(s)

Sroczynski G1;Esteban E1;Engel J2;Hillemanns P3;Petry K-U4;Krämer A5;Schnell-Inderst P1;Mühlberger N1, Siebert U*6 1UMIT - University for Health Sciences, Medical Informatics and Technology/ ONCOTYROL - Center for Personalized Cancer Medicine, Hall in Tyrol/ Innsbruck, Austria, 2Munich Cancer Registry of the Munich Cancer Centre, Clinic Grosshadern, Ludwig-Maximilians-University, Munich, Germany, 3Hannover Medical School, Hanover, Germany, 4Department of Obstetrics and Gynecology, Hanover Medical School, Hanover, Germany, 5School of Public Health, University of Bielefeld, Bielefeld, Germany, 6UMIT – University for Health Sciences, Medical Informatics and Technology / ONCOTYROL / Harvard University, Hall i. T./ Innsbruck / Boston, Austria

OBJECTIVES: Using a benefit-harm frontier (BHF) approach, we systematically compared benefits and harms of different HPV- and cytology-based primary cervical cancer screening strategies in Germany. METHODS: A previously validated and published Markov modelwas used to analyze the trade-off between benefits and harms of different screening strategies differing by length of screening interval and test algorithms, including cytology alone, HPV testing alone, in combination with cytology or with cytological triage of HPV-positives. We used published German clinical, epidemiological and international test accuracy data from meta-analyses. Predicted outcomes included reduction in cervical cancer incidence and unnecessary treatment (defined as conizations of lesions

Conference/Value in Health Info

2013-11, ISPOR Europe 2013, The Convention Centre Dublin

Value in Health, Vol. 16, No. 7 (November 2013)

Code

PRM1

Topic

Methodological & Statistical Research

Topic Subcategory

Confounding, Selection Bias Correction, Causal Inference

Disease

Oncology, Pediatrics, Reproductive and Sexual Health

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