OBJECTIVES: Patient Reported Outcomes (PROs) play an important role in patient-centered research where compliance is important. To better understand patient preferences when participating in PROs, survey research was conducted in 2013. This presentation investigates what impacts patient satisfaction, drop-out and compliance. METHODS: An internet-based survey was administered to a global sample of patients who participated in at least 1 clinical trial that included patient diaries in the past 2 years. The survey asked questions about the most recent trial with a diary focusing on the patient’s diary experience. RESULTS: 398 patients provided complete responses. On a scale of 1-7 (1=Very Bad; 7=Very Good), mean satisfaction rating=5.4. Satisfaction was categorized for sub-group analysis purposes: Positive Satisfaction (75%); Ok Satisfaction (16%); Negative Satisfaction (9%). Time per diary entry had the biggest impact on satisfaction.  Those whose diaries took