OBJECTIVES: The current prevalence of Multiple Sclerosis (MS) in Slovakia ranges from 100 till 150 cases per 100 000, actualized by 112 cases with insurance data. There are approx. 6 100 MS diagnosed MS patients. The objective of this paper was to find out all possible data about patients and for patients. METHODS: We conducted a research in collaboration with MS patient organizations. No HCP were involved, patient investigators were trained. A. Demography, treatment and socioeconomics (53 items), B. Specific questionnaire (31 items). We disseminated 500 questionnaires, 356 valid questionnaires were at the end evaluated, 78% women, 20% men (2% n. a.), average age 48.5 ± 11.9 , range 23-78 y, median 49.5 y, 52% college/gymnasium, 24% university, equal w + m (p=0.460). RESULTS: First symptoms related to SM raised average in the age of 30.9 ± 9.2 y (median 30 y), 12% before the age of 20, 18%  after 40 , 41% were diagnosed until 6 months of the first visit by physician, another 21% in 1 y. 30% were diagnosed after more than 2 y. 45%  EDSS 4-6.5, 33% EDSS 0-3 and 16% EDSS 7-9.5 (6% did not announced), 60% impaired with walking, 10% wheelchair, 2% in bed, 51% with assistance by daily activities, 9% by any activity. With rising EDSS MS therapy declines and other therapy is rising. CONCLUSIONS: The patients with MS in Slovakia, even with a relatively generous support from health care and social care and with available conventional or disease modifying therapy (DMT) suffer a significant decrease of their QoL.