OBJECTIVES: To estimate the economic burden of moderate to severe psoriatic arthritis (PsA) on workplace and household productivity using data from RAPID-PsA. METHODS: The ongoing Phase 3 RAPID-PsA trial (NCT01087788) recruited patients (pts) with active PsA. Impact of PsA on workplace and household productivity and daily activities was assessed at study baseline, using the validated arthritis-specific Work Productivity Survey (WPS). RESULTS: At baseline, pts had a mean age of 48 years and 55% were female; 61.6% had psoriasis skin involvement ≥3% body surface area. 59.5% of pts were employed, 14.0% work disabled due to PsA, and 13.5% retired. Overall, a high burden of PsA on workplace and household productivity and on social activities was reported, with on average >1 week (wk) of paid work affected and >2 wks of household duties or social activities affected per month. Household productivity losses were on average, up to 2 to 3 times higher in non-employed or disease work disabled pts vs employed pts: on average household duties were affected 18 days or 26 days vs 10 days/month, respectively. Employed pts with manual jobs reported higher productivity losses at work and within the home vs those with non-manual jobs. Overall, 41.8% of pts required regular assistance from relatives, friends or paid caregivers in their usual activities because of PsA. These pts reported on average 2 to 3 times higher workplace and household productivity losses vs pts who did not require help. CONCLUSIONS: PsA is associated with a high burden of disease on workplace and household productivity that could lead to large financial burden for pts and society. Effective PsA treatments are needed to prevent disability and work losses, and reduce economic burden of the disease.