OBJECTIVES: Health Transformation Program(HTP) started in year 2003 by MoH of Turkey. All health system changed dramatically. It had impact on all health consumptions and expenditures. The aim of this study is to show the impact of HTP on the imported pharmaceuticals(IP) and local manufactured pharmaceutical(LMS) sales in Turkey.  METHODS: Pharmaceutical retail sales data in units and volume(US$) from year 1998 to 2012 were retrieved from IMS Dataview. Local and import consumption trends were reviewed. The data was analyzed with Microsoft Excel 2010. RESULTS: Total unit sales were 689M in 1998, 698M in 2002 and 1768 M in 2012; after 10 years of HTP. Total sales were 1937M,  2526M and 8000 M USD for the same years, respectively.   Between 1998 and 2012, CAGR(Cumulative Annual Growth Rate) of unit sales was 7%, while the majority of this growth came from HTP(9,7% after HTP  vs 0,3% before HTP). There was no significant change in unit sales between 1998 and 2002; total CAGR was 0,3%. Sales between 1998 and 2012 in USD had an average growth rate of 10,7%. Comparing CAGR for before and after HTP; LMP was 1,5% before and 7% after while IP showed an inverse ratio with the total and LMP values and was 23,5% and 13,1% before and after. In the beginning of the 15 years period market share for local manufacturing 92,6% in units and 80,8% in USD; in 2002 dropped down to 88,8%  in units and 65,7% in USD, and finally in 2012 to 75,2% in units and 49,8% in USD. CONCLUSIONS: The percentage of IP both in  units and volume increased in years. This increase may be caused by different reasons, particularly new oncology and biotechnology molecules. It was observed that the volume increase in IP or decrease in LMP  was limited by the HTP.