OBJECTIVES: This study aims to evaluate the outcomes related to heart transplantation in adult recipients at 6±1 (Group I),12±2 (Group II), 36±6 (Group III), 60±10 (Group IV) or 120±20 (Group V) months after receiving the allograft.  METHODS: A multicenter, cross-sectional study was conducted in different transplant units from Spain (n=14). Patients (aged >18 years) with a heart transplant (HTx) due to congestive heart failure and living with a single functioning graft were proposed to participate. Clinical status was assessed with the New York Heart Association Scale. Besides, participants completed the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EQ-5D. Other measures of social support and caregivers’ burden were also included. Differences between groups were studied (Chi-squared, Kruskal-Wallis and Mann-Whitney U with Bonferroni correction tests). Multivariate regression analyses were applied to examine the association of clinical and socio-demographic variables with questionnaires’ scores. RESULTS: A total of 303 transplant recipients (77.9% males) with a mean age(SD) of 56.4(11.4) years were included. High levels of health-related quality of life (HRQoL) were found at all stages after transplant. However, a slight decrement was detected after 10 years since transplantation (p≤0.033). EQ-5D utility mean(SEM) scores were: Group I-0.81(0.03)-; Group II-0.82(0.03)-;  Group III-0.85(0.03)-; Group IV-0.86(0.02)-; Group V-0.75(0.03)--). VAS values (EQ-5D) were close to those of the general population, with the exception of patients at 10 years since transplantation whose scores were lower. Multivariate analyses showed that this decrement in well-being was related to comorbid medical conditions, severe vascular disease of allograft and the number of hospitalizations (EQ-5D:  48.4% of explained variance, F4,164= 38.46, p<0.001; KCCQ-overall functional score-: 45.0% F3,198= 54.073, p<0.001). CONCLUSIONS: : HTx outcomes in Spain seem to be satisfactory with good achievements in HRQoL and utility scores.