OBJECTIVES: To evaluate, compare, and assess the quality of the studies on the cost-effectiveness of enhanced management (either as adjunct to usual care or alone) vs.usual care alone or none at all. METHODS: Scientific databases (ScienceDirect, Wiley Online Library, (EbscoHost – MEDLINE, CINAHL, PSYInfo), (OvidSP – EMBASE, MEDLINE), and Scopus) were searched for published journal articles in English language from year 1990 to 2012, using the search terms “asthma AND (intervene OR manage) AND (pharmacoeconomics OR economic evaluation OR cost effectiveness OR cost benefit OR cost utility)”. Hand search was done for local publishings. Only studies with full economic evaluation on enhanced management (either as adjunct to usual care or alone) were included. Selected studies were data abstracted and assessed for their quality of economic evaluation using the Quality of Health Economic Studies (QHES) instrument, and quality of evidence. RESULTS: A total of 14 studies were included. There were three distinct modes reviewed: environmental control, self-management, education. Most of the enhanced managements were found to be cost-effective with ICER ranged from dominant to $26700.00 per unit of outcome. Overall, the mean score of QHES was 76.69% (SD 9.26). For the quality of evidence, 'clinical effect sizes, adverse events & complication', baseline clinical data, resourse use, and costs components were ranked mainly 1 or 2 (best or nearly best) in all studies. For ‘utilities’ component, one study ranked 5 because it used visual analogue scale to obtain patient preference values. CONCLUSIONS: Despite the low qualities of the reviewed studies, it overall suggests that enhanced management (either as adjunct to usual care or alone) is mostly cost-effective than the usual care or none at all; environmental control is considered the most cost-effective, and there is also strong evidence for self-management, but provided the mode of it is made available, affordable, and accessible then this shall be worth to be adapted in one’s setting.