OBJECTIVES: To evaluate the cost effectivenss of Thiopentone and Propofol for over night induction anesthesia in a tertiary care hospital. METHODS:  A prospective  observational study in which  the patients scheduled for general anaesthesia were adminsitred EQ5D 5L(Qol question aire) after six hour and 24 hours of administering Induction Aneasthesia.  Kuppuswamy scale was applied to asses the socioeconomic status along with the demographic detials  RESULTS: The average of EQ5D5L scores for Propofal was 14.2 and for Thiopentone 16.0. The cost of the Propofol brand used in hospital were 250INR and 260INR. Thiopentone , only one brand was avialable costing 62 INR. The Propofol was the most commonly used induction anesthetic and it costs more than 4 times of Thipentone. The patients  socioeconomic categorirzation based on Kuppuswmy Scale  revealed nearly 50% of patients belonged to lower middle class and 35% middle class and rest of the patients to Upper class. Incremental cost effectivness ratio for Thiopentone agianst Propofol was found to be -110;    CONCLUSIONS: The Propofol although expensive does not offer any advantage over the Thiopentone as for quality of life among patients who under went induction anethesia