OBJECTIVES: Assess health-related quality of life (HRQoL) of patients with CAD. METHODS: The main observational study cohort enrolled consecutive patients admitted in ICU at tertiary care hospital and diagnosed with CAD. Demographic information, risk factors for CAD, and angiographic findings were collected. EQ-5D was administered at 1-year follow-up. EQ-5D levels were dichotomized: 'no problems' (level 1), 'any problem' (levels 2 and 3). Linear stepwise regression was used to assess predictors of all 5 health states (mobility, self-care, usual activities, pain/discomfort, anxiety/depression). The independent variables studied include age, hypertension, diabetes, CHF, gender, prior MI, final diagnosis, MI type, and final treatment. Respondents reporting problems EQ-5D dimensions were stratified by presence of diabetes and compared. RESULTS: Of 960 CAD patients enrolled for the main cohort study (30% diabetic), 306 (male, 230; diabetics, 64) responded HRQoL questionnaire at 1-year. On liner regression, presence of diabetes was independent predictor of 4/5 EQ-5D HRQoL dimensions: mobility (p=0.019), problems performing usual activities (p=0.041), pain/discomfort (p<0.001); anxiety/depression (p=0.001). At 1-year, mean EQ-5D utility index score and VAS score were significantly lower for diabetes vs non-diabetics (0.76±0.13 vs 0.83±0.15, p=0.0003 and 67.8 ± 8.8 vs 73.6±5.4, p=0.0001, respectively) with more problems with performing usual activities (56.3% vs 41.3%, p=0.04), pain or discomfort (51.6% vs 17.8%, p=0.0001) as well as anxiety/depression (32.8% vs 14.9%, p=0.002). CONCLUSIONS: Among CAD patients with diabetes, HRQoL was lower across all health dimensions measured by the EQ-5D; except mobility and self-care. Individualised therapeutic management programs could be considered in order to improve the HRQoL of CAD patients with diabetes.