OBJECTIVES: Osteoporosis is a chronic disease which has impact on specific aspects of health such as pain, physical functioning, social and mental functioning and loss of personal independence. Generic questionnaire EQ-5D explores similar dimensions and therefore is usually used as a questionnaire for assessing the concurrent validity of the specific osteoporosis questionnaires. The objective of this study was to explore for a potential correlation between the similar dimensions of the specific osteoporosis questionnaire QUALEFFO-41 and EQ-5D. METHODS: Analyzed data were a part of the study that included 50 patients with osteoporosis and vertebral fractures conducted during the period June 2010 - October 2011. The correlation between the questionnaires was assessed using the Spearman's correlation coefficient. RESULTS: Strong correlations were found between EQ-5D index / VAS score and QUALEFFO-41 total score (ρ=-0.73 and ρ =-0.57, p<0.001, respectively). The EQ-5D dimensions “Pain/discomfort”, “Mobility”, “Activities”, “Anxiety/Depression” similar to QUALEFFO-41 dimensions “Pain”, “Physical function”, “Leisure, social activities”, “Mental function” were also strongly correlated (ρ=0.42, ρ =0.76, ρ =0.46 and ρ=0.32, p<0.001, respectively). CONCLUSIONS: Strong correlations between similar dimensions of the compared questionnaires were notified. Negative values of the Spearman's correlation coefficient indicated that total score of the QUALEFFO-41 were scored in the reverse order. There was only one QUALEFFO-41 dimension (“General health perception”) that is not similar to any of the EQ-5D dimensions. Although there was a strong correlation between the total scores of compared questionnaires, the results of the EQ-5D questionnaire should be observed with caution, because it does not contain all important dimensions that osteoporosis affects.