OBJECTIVES: Limited data is published on baseline characteristics of patients diagnosed with vitreomacular traction (VMT) or different macular hole (MH) stages. Aim of our study was to describe the baseline patient and ocular characteristics, and the management of patients diagnosed with diseases of the vitreomacular interface. METHODS: This was an observational study with retrospective design. The study sample included patients from a large tertiary care ophthalmology center in Flanders, who had at least 1 outpatient visit at the study center between July 2009 and May 2013. Patients presented with or without visual symptoms and were examined using optical coherence tomography (OCT) in both eyes. Patients diagnosed with other retinal diseases were excluded from this study. This analysis reports on the VMT cohort only. RESULTS: The study sample included a total of 509 patients of which 156 patients (191 eyes) presented with VMT. Mean (SD) age was 72.8 (9.8); 59% were female. Majority (73%) was referred by an ophthalmologist for symptoms of general vision loss (60%) and/or metamorphopsia (23%). Mean follow-up was 1.64 years. Eyes in which a vitrectomy was performed (n=41) presented with worse visual acuity (VA) compared with eyes managed through observation (0.43 versus 0.55; p=0.029). However, VA in fellow eye was significantly better in eyes managed with vitrectomy (0.7 versus 0.56, p=0.039). Metamorphopsia (61% versus 37%, p=0.005) and concomitant ERM (20% versus 9%, p=0.049) were significantly more prevalent in eyes managed through vitrectomy compared with observation. CONCLUSIONS: In a real-life population, visiting the outpatient clinic of a large tertiary care ophthalmology center, 31% of patients presented with VMT. Patients were predominantly managed though observation. Worse visual acuity of fellow eye, and presence of metamorphopsia or ERM were significantly associated with occurrence of vitrectomy.