OBJECTIVES: Are the relative weights of different dimensions of health different when determined by their impact on subjective well-being (SWB; 2 types of self-report: retrospective global evaluation, momentary experience) and health (3 types of self-report:  retrospective global evaluation, future prospect, momentary experience). METHODS: The study population consisted of persons experiencing psychosomatic, psychological and somatic illness, and members from public. The experience sampling study took 6 days, during which momentary self-reports of health and SWB were obtained. In addition, participants completed retrospective global evaluations of health (EQ-5D), SWB (Life Satisfaction Scale) and preference for a future prospect of health (time trade-off). Regression analysis was used to determine relative weights of EQ-5D dimensions on the outcomes. RESULTS: 139 participants were included. Some/moderate problems in usual-activities and anxiety/depression were associated with the largest drop in health for all three types of self-report. Moderate anxiety/depression had a larger impact than moderate problems in usual-activities in momentary as compared to retrospective health-reports. Moderate problems in usual-activities and anxiety/depression and self-care were associated with a drop in retrospective and momentary SWB. Moderate problems in usual-activities was associated with the largest drop in retrospective SWB, while moderate anxiety/depression was associated with the largest drop in momentary SWB. Comparing the relative weights, it was shown that anxiety/depression was more important relative to usual-activities in momentary experiences than in retrospective evaluations. CONCLUSIONS: Relative weights of health domains are different, depending on the type of self-report (global or momentary) and concept of value (health or SWB) used. Most notably, the relative weight of anxiety/depression is larger when using a momentary measure, and when taking SWB as the outcome of interest. This finding warrants further discussion and research on the place and value of momentary measures of experience and SWB as outcome in health (economic) evaluation.