OBJECTIVES: Despite the availability of highly efficacious treatment options for Opioid addicted patients, these patients often suffer from poor outcomes due to low rate of compliance. To improve compliance and achieve better health outcomes we developed a patient supported system that assisted patients with drug information, training and timely reminders. METHODS: The current compliance rates were reviewed using published literature. Information on standard of care was collected from prescribers and treatment centers.  2000 patients were enrolled 50:50 in study and control arm. Duration of study was six months. The data for number of missed appointments, prescription refills and health outcomes were collected from both arms. A comparative analysis was used to determined a need for additional treatment support RESULTS: The support system provided telephonic support and care coaching to opioid addicted patients. Trained staff of RN’s and CDC’s were able to discuss treatment, disease and other issues in an effort to keep patients compliant and on therapy. As compared to the control arm, patients in the study arm stayed on therapy for an additional average 3 months. This support system reduced the need for ancillary support and led to 30% cost savings for the system. CONCLUSIONS: Patient support systems can significantly improve patient compliance by providing support, training and reminders to patients. Such programs also provide valuable “real world” data and save costs for treating patients. Results of this program demonstrate that it is more cost effective for payers to pay for additional levels of drug therapy than to treat patients for relapse in other care settings.