OBJECTIVES: This study was to compare health-related quality of life of patients with hypertension to people without hypertension.   METHODS: Using the 2007 NHANES of Korea, EuroQol (EQ-5D) was used to estimate a relation between quality of life and hypertension. In the analysis, adults (age≥19 years old) at the time of the survey were included. EQ-5D as well as each 5 category such as mobility, self-care, usual activity, pain/discomfort and anxiety/depression were considered for the analysis. For the estimation in EQ-5D, a generalized linear model with a logit link and the binomial family was used because EQ-5D was a proportion variable and had high negative skewness. In each specific category, there were 3 categories indicating good (1) to worse (3). Thus, ordered logit regressions were used for the analyses. In all analyses, age, gender, types of insurance, income, years of education and comorbid conditions were included. Survey weights were incorporated in the analyses to consider the survey design.   RESULTS: A total of 2767 subjects was available. Among those, 518 (18.7%) subjects had a hypertension based on self-report on whether they had hypertension or not. Mean (SD) in quality-of-life of patients with hypertension was 0.84 (0.19), while mean (SD) of patients without hypertension was 0.93 (0.12). Among patients with hypertension, 51.7% were elderly (age>=65 years) and 59.5% were female. Among patients without hypertension, 16.6% were elderly and 57.1% were female. Patients with hypertension as compare to people without hypertension were lower in quality of life by -0.20 (p-value: 0.038) after controlling other factors. Patients with hypertension were worsen in mobility and usual activity, but self-care, pain/discomfort and anxiety/depression had no difference from people without hypertension. CONCLUSIONS: Patients with hypertension as compared to people without hypertension were lower in quality of life mostly due to difficulties in mobility and usual activity.