OBJECTIVES: - To compare racial variations in risk factors associated with incidence of Chronic Kidney Disease (CKD) in a sample population (age>11 years) and look for possible early indicators. METHODS: - A retrospective study was conducted using the NHANES 2003-2004 database comprising of a nationally representative sample containing nutritional and health records. Patients were screened on the basis of their Glomerular filtration rates and a sample with an estimated Glomerular Filtration Rate (eGFR) < 60ml/min/1.73m2 was included in the study. The eGFR was calculated using the 6-variable MDRD equation. Demographics and laboratory records such as Blood Pressure, cholesterol, glucose, albumin, serum creatinine and Vitamin D levels were recorded. RESULTS: - An eGFR < 60 ml/min/1.73m2 was observed in 413 (5.6%) of 7344 NHANES participants; of which 71.16% were Non-Hispanic Whites, 10.89% were African-Americans and 11.13% were Mexican Americans. Lower prevalence amongst African-Americans and Mexican-Americans was not seen to be uniform in higher stages of CKD. Vitamin D deficiency was noticeable in African-Americans and Mexican Americans compared to Non-Hispanic Whites at 15.28ng/ml (95% CI 12.82-17.74), 17.17ng/ml (95% CI 14.87-19.47) and 24.46ng/ml (95% CI 23.46-25.47) respectively. Serum Creatinine levels were recorded as 1.717mg/dl (95% CI 1.287-2.147), 2.351mg/dl (95% CI 1.565-3.136) and 1.355mg/dl (95% CI 1.303-1.406) for Mexican-Americans, African-Americans and Non-Hispanic Whites respectively. CONCLUSIONS: - Higher prevalence of African-Americans and Mexican-Americans participants in the later stages of CKD may be associated with lack of healthcare access/ socio-economic factors. The proportion of population suffering from hypertension and diabetes increased significantly from stage 1 to stage 5 along with marked racial disparities in the higher stages of CKD. Markers such as Vitamin D deficiency, Hypertension & serum creatinine levels can be better monitored by regular blood tests and prove to be effective early indicators in the progression of CKD.