OBJECTIVES: To compare value sets derived from EQ-5D US tariffs and VAS and TTO in individuals with chronic pDPN/PHN. METHODS: This analysis was conducted using baseline responses from 3 longitudinal surveys of adults with ≥3 months of pDPN/PHN who were receiving pain medications. Of them, 2719 completed the EQ-5D and VAS and, 2109 completed TTOs. Three value-sets were derived using: the EQ-5D classifier (US-value-set), VAS, and TTO, which elicits patient willingness-to-trade time for reduced pain. Generalized linear models were used to compare the covariate-adjusted values, adjusting for age, income, overall pain quality, and pain severity (PS) using numerical rating scale ranging from 0 ("no pain") to 10 ("pain as bad as you can imagine"). Derived values were compared along PS, across all respondents and by subgroups according to degrees of social/psychological difficulties due to pain. RESULTS: Mean respondent age was 55.48 (±10.65) years and 58.73% reported having a PS≥6. Due to pain, 84% reported feeling older, 60.30% reported not feeling like going out and 60.29% wanted to be left alone. Mean values for EQ-5D, VAS and TTO were 0.594 (±0.215), 0.482 (±0.231) and -6.010 (±17.573), respectively. Mean covariate-adjusted values were 0.586 (±0.128), 0.471 (±0.075) and -6.156 (±4.151), respectively. All values decreased monotonically as PS increased. This monotonic relationship was strongest for TTO (resulting in a value of –11.98 at PS=10 after covariate adjustment), followed by the EQ-5D, and VAS (p<0.001). Similar results were found in stratified groups, especially in those with greater pDPN/PHN-related social/psychological difficulties compared to other patients (p<0.05). CONCLUSIONS: All three value-sets show scores significantly related to PS. Findings suggest that value-sets with lower-end constrains (VAS, EQ-5D) are likely to underestimate the true value of preventing pain and may not lead to correct prioritization when considering health states that involve moderate to severe pain.