OBJECTIVES: To examine the effect of an employer-sponsored, pharmacist-provided medication therapy management program (MTM) on clinical outcomes and process measures in patients with diabetes and hypertension METHODS: A prospective, intent-to-treat, pre-post longitudinal study.  Patients were Lucas County employees and dependents with diabetes, hypertension, or both.  The MTM services were provided by independent pharmacists in Northwest Ohio at seven sites.  ADA and JNC-VII guidelines were used to design interventions and set patient goals.  Data was analyzed using SPSS v17.0 for three groups – hypertension only, diabetics, and hypertensive diabetics.  Wilcoxon signed-rank test was used to compare 2 time points and the Friedman test was used to compare readings at baseline, 6,12,and 18 months. RESULTS: Five hundred eighty six patients enrolled at baseline.  The Hypertension only group mean systolic blood pressure (SBP) improved from 135.37 ± 18.85 to 130.33 ± 18.35 (p=0.057).  Diastolic blood pressure (DBP) improved from 81.71 ± 10.70 to 80.35 ± 11.12 (p=.386).  Uncontrolled hypertensive patient’s SBP mean improved from 153.03 ± 12.37 to 138.91 ± 19.74 (p<0.01).  DBP improved from 97.07 +  5.71 to 85.6 ± 13.20 (p<0.05).  For hypertensive diabetic patients SBP improved from 134.59 ± 18.99 to 128.35 ± 18.55 (p=0.20).  DBP improved from 81.52 ± 11.25 to 79.52 ± 12.08 (p=0.75).  Uncontrolled diabetic hypertensive patients SBP mean improved from 145.96 ± 13.83 to 135.29 ± 17.62 (p<0.05).  DBP improved from 87.51 ± 6.54 to 82.71 ± 11.92 (p=0.439).  For uncontrolled diabetic patients A1c improved significantly from 8.02 ± 1.31 to 7.41 ± 0.99 (p<0.001). Patients with controlled A1c at baseline were able to maintain control for the 18 months of participation in the study.  Upon being advised by their pharmacists more patients visited their dentist, podiatrist, and ophthalmologist. CONCLUSIONS: Pharmacists were able to help patients maintain A1c and BP goals thereby preventing future complications and costs to the employer.