TREATMENTS PATTERN AND OUTCOMES OF OVARIAN CANCER PATIENTS IN A PATIENT-CENTERED RETROSPECTIVE RESEARCH REGISTRY
Author(s)
Cai B1, Saokaew S2, Stenehjem D1, Kuo KL3, Bauer H3, Albright F3, Brixner D31University of Utah, Salt Lake City, UT, USA, 2University of Phayao, Phayao, Thailand, 3University of Utah, College of Pharmacy, Salt Lake City, UT, USA
OBJECTIVES: Ovarian cancer is the fifth most common cause of cancer death in women; therefore study investigating treatment patterns, heath care charges and overall survival is warranted. This study aims to determine ovarian cancer treatment pattern and charges stratified by initial diagnosis stages. METHODS: Patients were retrieved from linking records in the University of Utah Enterprise Data Warehouse, the Utah population database, and the Huntsman Cancer Institute Tumor Registry. We included female patients with age ≥18, having one or more of ovarian cancer ICD9-CM code (183.0), with informative staging data, and at least 2 encounters during 1995 to 2010. Treatment patterns, health care charges, and survival were stratified by stage at initial diagnosis. RESULTS: Of 495,523 female patients, 379 ovarian cancers were identified. Mean age was 51.9, 54.1, 59.3, and 63.5 years at stage I (n=83), II (n=31), III (n=176), and IV (n=89), respectively (p<0.001). The mean Charlson co-morbidity score was significant between the stage groups (p<0.001) as was the distribution of age groups (p=0.004). Patients received surgery as first treatment, then chemotherapy, and radiation in all stages. The largest annualized charges were incurred in stage IV patients ($72,579), followed in decreasing charge magnitude by stage III ($48,765), II ($50,303), and I ($29,479), respectively. Five year overall survival was 81.93%, 77.42%, 49.43%, and 15.73% for stage I, II, III, and IV patients, respectively. CONCLUSIONS: Our findings show that the treatment and time to treatment in our cohorts mostly follow NCCN guidelines. Patients presenting in later stages, as expected, experience reduced survival and increased health care charges. These results provide unique information on the utilization and treatments in ovarian cancer towards the further conduct of oncology outcomes research or economic evaluation. Further study identifying predictors of long term survival and reduced resource utilization is needed.
Conference/Value in Health Info
2012-11, ISPOR Europe 2012, Berlin, Germany
Value in Health, Vol. 15, No. 7 (November 2012)
Code
PCN31
Topic
Clinical Outcomes
Topic Subcategory
Relating Intermediate to Long-term Outcomes
Disease
Oncology