OBJECTIVES:  The mission of the health system is providing health of the society and satisfaction is an aspect of the human health. Measurement of patients’  satisfaction is a way for evaluating health system services. The purpose of this study was to measure patients’ satisfaction with pharmacy physical space, services and staff behavior. METHODS: A total of 797 pharmacy customers randomly selected from 22 districts of Tehran -the capital city of Iran- completed an anonymous, self-administered questionnaire. RESULTS: Including 3.5 as moderate level of satisfaction, there was some dissatisfaction (mean<3.5, pvalue<0.05) about the allocation of sufficient time to respond to patients enquiries, consultations (about patient’s disease, non-medical treatments, herbal medicines and supplements), arrangement of service stages, honesty in delivery of scarce medicines, waiting time, compliance of number and type of dispensed items with physician prescription, convenience of pharmacy's lobby space and suitable physical space for communication with pharmacy staff. In addition, according to the result of the Friedman test, the most important issue for patients in the study was observation of courtesy and respect by pharmacy staff. Overall satisfaction measured by weighted values (based on priorities identified by participants) of three components of satisfaction (physical space, service quality and staff behavior) was statistically different from satisfaction measured based on common method (3.48 vs. 3.40, pvalue<0.05). CONCLUSIONS: Pharmacy customers expect pharmacists to be more involved in providing advice. Also it seems that improvement in design of pharmacies physical space including allocation of an appropriate space for patients to talk with pharmacy staff, specially pharmacist, can increase customer’s satisfaction. Observing customers’ priorities may have an important influence on interpretation of the results of satisfaction studies and, therefore, on the selection of interventions.