OBJECTIVES: Using information collected from leading Turkish gynecologists, the costs of different clinical practices of laparoscopic surgery (LS) for endometriosis treatment were compared. METHODS: Top gynecologists from Turkey were interviewed regarding the best practices to treat endometriosis, including hospitalization, tests ordered pre- and post surgery, and the number of follow-up visits per patient. Physicians' views were split into two camps with a few opinions in the middle.  The diverging physician opinions were compared and using the physicians’ recommended laparoscopy procedures, the cost of endometriosis treatment was estimated using Social Security Institution data. RESULTS: The answers regarding hospitalization following laparoscopic surgery differed between “hospitalization for all patients” and “no hospitalization” after LS.  The percentage of patients recommended for chest radiography and electrocardiogram (ECG) also varied between 30% and 100%.  The number of follow-up visits differed with suggestions for both no and one follow-up visit. Using the interview results and the assumption that 5% of Turkish women between ages 18 and 49 (N=1,000,000) suffer from endometriosis, the total cost of laparoscopic treatment was estimated for two sets of recommendations: a) the physician does not hospitalize patients, suggests chest radiography and ECG  for 30% of patients, and does not follow-up with any of the patients after LS, and b) the physician hospitalizes all patients for one night, suggests chest radiography and ECG for 100% of patients, and follows-up with all patients after LS. Depending on physicians’ preference of treatment procedures, projected costs varied from 200.24, to 241.30. CONCLUSIONS: Different clinical perspectives and practices of laparoscopic treatment for endometriosis affect cost of therapy by as much as 41,06 per patient. When combined with the estimated 1 million endometriosis patients in Turkey, total cost differs 41,060,000.  Developing a standard procedure for LS may help lower aggregate costs and cost variation of procedure.