OBJECTIVES: The Institute for Quality and Efficiency in Health Care (IQWiG) developed—in a consultation process with an international expert panel—the efficiency frontier (EF) approach to satisfy the legal requirements for economic evaluation in Germany’s statutory health insurance system.  Here we evaluate established tools for assessing and communicating uncertainty in terms of their applicability to the EF approach and, where necessary, suggest adjustments to them. METHODS: Tools to dasplay uncertainty were applied to the EF approach with a simulated data set. The tools are (i) displays of overall uncertainty (scatter plots, confidence bands, contour plots); (ii) displays of uncertainty around the reimbursable price (confidence intervals, a modified cost effectiveness acceptability curve, the net health/ monetary benefit approach), and (iii) the ANCOVA approach. RESULTS: We found that, within the EF approach, the substantial implications of most tools was not always easy to interpret. Hence, we propose the use of price reimbursement acceptability curves or the net health benefit approach. CONCLUSIONS: This closes a gap for handling uncertainty in the economic evaluation approach of the IQWiG methods. However, the role of statistical testing in determining reimbursable prices is yet to be defined.