OBJECTIVES: About 50 million dengue infections occur every year worldwide. New dengue vaccines are currently in development and policymakers need appropriate economic studies to determine their potential impact. This study aims to assess the burden of dengue disease in Colombia and its costs.  METHODS: We estimated the disease burden of dengue (D) and severe dengue (SD) in Colombia for 2011-2014 based on a dynamic model designed with the best available evidence and validated with the occurrence data. The annual number of D and SD cases receiving medical care were determined. We calculated the average cost of care per patient with D and SD based on a bottom-up costing of cases attended in the Colombian health facilities, additional costs were estimated from programs of vector control dengue at different administrative levels. Based on the occurrence of disease and extrapolation of national vector control programs we estimated a total annual cost of burden of dengue in Colombia.  RESULTS: Our dengue model estimated in 2011 34,751 D consults (13,900 outpatients, 20,851 inpatients), 988 SD cases, and 102 (78-123) deaths due to dengue. In 2012 22,247 D (8899 in- 13,348 out-patients), 863 SD, and 103 (79-124) deaths. In 2013 27,588 D (11,035 in- 16,553 out-patients), 1032 SD and 105 (80-126) deaths. Finally in 2014 25,957 D (10,383 in- 15,574 out-patients), 913 SD, and 106 (80-127) deaths. The total attention costs in 2011 raised to US$ 16.86 million.  That year the total cost of Dengue’s vector program amounted to US$ 37.08-42.41 million. The total annual cost of dengue would amount to US$ 53.94-59.27 million in a year without outbreak.  CONCLUSIONS: Burden of dengue disease in Colombia involves a high economic impact to the health system. In 2011 between 28.4-31.3% correspond to medical attention cost and between 68.7-71.6% are due to dengue vector control program.