OBJECTIVES: To estimate economic value of informal care provided to patients in situation of dependence with multiple sclerosis (MS). METHODS: Patients with MS and their caregivers were identified through EDAD survey. The number of hours of informal care provided was estimated. The method of cost replacement was used to assess the economic value of this care. Two assessment scenarios were considered using “The Elderly in Spain” report (IMSERSO, 2008): the first one considered the mean wage per hour of public service for home help of the 3 Autonomous Regions of lower value, whereas the second scenario took into account the national mean wage in order to estimate cost per hour.     RESULTS: EDAD survey identified 368 patients with MS and some kind of disability. Average age was 64.26 years (SD: 16.82) and 73.91% were female. Average daily hours of care provided to people with MS amounted to 10.27 (95% CI: 9.46 – 11.07). On an annual basis, average informal care at home equalled 3,860 hours per MS patient. According to the assessment scenarios considered, total mean costs of informal care at home ranged between 29,604 and 49,057 € per patient and year. When only the main informal carer at home is considered, estimations yield 3,585 hours per MS patient and year, whereas valuation ranged between 27,493 and 45,559 €.  CONCLUSIONS: Informal care of MS represents a high social burden. Dependence grade influences the need to provide personal care. According to 2008 values, value of informal care provided to people with MS is estimated at 29,604 – 49,057 € per patient and year.