OBJECTIVES: Formulary system of medical provision is created in Ukraine.. The Order of MOH of Ukraine № 529 “About Creation of Formulary System for Health Institutions” was approved in 2009. The Fourth edition of State Formulary approved in 2012. METHODS: We used comparative analysis of drug information for children from all editions of the State Formylary (2009-2012) were conducted.The State Formylary contains a special section for children "Neonatology medicines." All medicines in this section are classified into 11 pharmacological groups. RESULTS: In 2009 were  included 95 medicines for children, 2010 – 91, 2011 – 81, 2012 - 78 respectively. For the first time in 2011 the State Formylary were included three preparations for replacement surfactant therapy for newborns with respiratory disorders. It’s Ukrainian-made preparation "Neosurf" emulsion, and two imported medicines "Infasurf" suspension, and "Curosurf" suspension. We evaluated the costs of treatment were 223.2 € (1€ = 9.98 UAH), 404.5 €, 630.6 € respectively. Since 2007 for the state budget were purchased Curosurf, from 2008 - Neosurf, and 2011 - Infasurf. We found regional differences concerning the financing of these medicines. Curosurf funded by 11% of needs in Dnipropetrovsk, Donetsk regions, 10% - in Kharkiv region, 8% - in Lviv region, less than 5%  - all other 23 Ukraine regions. CONCLUSIONS: The results showed that in the State Formylary 2009-2012 the number of medicines for children  was decreased by 22%. The costs of treatment surfactant is high enough.It is established that the highest compensation surfactants were in the Crimea, Donetsk, Dnipropetrovsk, Lviv regions. Is grounded that is necessary the creation special Ukranian Formylary for children, which will include a larger number of children's medicines.