OBJECTIVES: To measure the impact of pharmacist-provided diabetes management program on the economic, clinical, and humanistic outcomes for the City of Toledo employees and their dependents for a period of 6 months. METHODS: This is a prospective, pre-post longitudinal study. Clinical outcomes collected were A1c, blood pressure (BP), and body mass index (BMI). These outcomes were measured at the baseline, 3 and 6 month visits. Economic outcomes include cost of physician office visits, emergency room visits, and inpatients days. These outcomes were measured at baseline and 6 month visits. Humanistic outcomes collected were quality of life (using Sf36v2), patient satisfaction, adherence with medications, and knowledge about diabetes. The quality of life and knowledge about diabetes were measured at baseline and 6 month visits. The patient satisfaction and adherence with medications (using Morisky scale) were measured at baseline and 3 months visits. Wilcoxon-Signed rank test was used to compare variables at two time points. Friedman test was used to compare variables at multiple time points. Preliminary data analysis for the period between baseline visit to 3 months visit is given below. RESULTS: Ninty five patients have been enrolled to date. Mean A1c's have decreased significantly from 7.78 at baseline visit to 7.44 at 3 months (p=0.05) (N=59). For Intention to treat population (baseline A1C>7), the decrease in A1c is even more significant (p=0.01) (N=33). Diastolic blood pressure has decreased significantly (p=.001) while systolic blood pressure and BMI have decreased non-significantly. Self monitoring of blood glucose has increased significantly (p=0.01). Patient satisfaction and adherence with medications has also improved significantly at three-month follow-up visit (p<0.05). Final results for the period between baseline visit to 6 months including economic outcomes will be presented at the ISPOR 14th Annual International Meeting. CONCLUSIONS: Preliminary data analysis showed that pharmacists can improve the clinical outcomes in patients with diabetes.