OBJECTIVES Diabetes is a debilitating and common illness that can lead to significant disability. Key patient-reported outcomes are important as they can influence productivity and patient health-related quality of life (HRQL). The objectives of the current research were to: (1) assess the current level of treatment satisfaction within existing oral anti-diabetics (OADs) and (2) determine the association between treatment satisfaction and productivity and HRQL. METHODS The current study design was a cross-sectional web-based survey of adults diagnosed with type 2 diabetes mellitus (T2DM) using OADs, but not insulin. Treatment satisfaction was assessed using the Diabetes Medication Satisfaction questionnaire (DiabMedSat). HRQL was examined with the EQ-5D instrument. The Work Productivity and Activity Impairment (WPAI) and Diabetes Productivity Measure (DPM) questionnaires were used to assess productivity. Pearson's correlations and linear regression models were used to assess strength and direction in association. RESULTS Of 2,074 survey respondents, 53% were men and mean age was 60 years (SD=10.83). 64% of respondents report being very/extremely satisfied with their diabetes treatments. Total DiabMedSat score was 79.5; higher scores were reported with the burden subscale (89.5) versus the efficacy and symptom (i.e. tolerability) sub-scales (69.8 and 69.5). There was a direct correlation between overall treatment satisfaction and higher EQ-5D scores (r2=-0.401, p<0.001), and increased work and life productivity (DPM: r2=0.595 and r2=0.640, p<0.001). Similar correlation results were observed with WPAI. After controlling for patient demographics, treatment satisfaction has greater effects on presenteeism (impairment while working) (WPAI: -0.472, 95% CI: -0.611 to –0.333, p<0.001) than absenteeism (missed work time) (WPAI: -0.057, 95% CI: -0.157 to 0.043, p=0.263). CONCLUSIONS Among T2DM patients, there is a high level of satisfaction with OAD therapies, though improvements could be made in efficacy and tolerability. Increases in treatment satisfaction can have a direct improvement on productivity and health-related quality of life.