OBJECTIVES Poor adherence to antihypertensive therapy increases patient risks of cardiovascular events. The objective of this study was to measure the effectiveness of an individualized educational program on medication adherence and blood pressure (BP) control. METHODS This was a six-month, longitudinal study with a prospectively identified intervention group and a retrospective control group. The Scott & White Health Plan enrollment and claim databases and EMR were utilized to identify continuously enrolled patients aged 18 years or older, diagnosed with hypertension, and treated with valsartan, aliskiren, or a fixed-dose combination of valsartan/hydrochlorothiazide or amlodipine/valsartan for at least three months prior to study enrollment. Patients meeting the inclusion criteria were invited to participate in the prospective intervention arm of the study, while those with geographic limitation served as controls. The intervention group received monthly personalized information about hypertension and treatment. A power analysis determined 150 participants would be required in each arm to detect a 3% change in MPR. The intervention and control groups were matched based on demographic characteristics and Charlson Comorbidity Index score. All interval data were analyzed using paired t-tests, while categorical data were analyzed using chi-square tests. RESULTS A total of 159 patients enrolled into the study (60% female; mean [SD] age, 62 [12.6] years). Analysis of 95 matched patients showed no significant mean (SD) change in MPR (86% [0.2] to 83% [0.25] vs. 85% [0.24] to 82% [0.29]; P=0.8), systolic BP (137.2 [15.1] to 136.3 [15] vs. 132.2 [14.8] to 136 [16.4] mmHg; P=0.2) and diastolic BP (72.6 [9.8] to 73.7 [13.1] vs. 72 [10.2] to 70.8 [10.5] mmHg; P=0.5) for the intervention and control groups, respectively. CONCLUSIONS Our preliminary analysis showed no significant change in medication adherence and blood pressure. A complete analysis is necessary to determine the impact of the educational tool.