OBJECTIVES: The Human Papillomavirus (HPV) is a known cause of cervical cancer and genital warts, and causes a proportion of vaginal, vulval, penile, anal, and head and neck (H+N) cancers. Quantifying the broader burden of HPV-related cancers is important as this group represents approximately 5.2% of all cancers. METHODS: Using cancer registry data covering the population of England (2003-2008), we examined incidence of HPV-related cancers. HPV-associated sites were identified (cervix, vulva, vagina, anus, penis and H+N) and grouped according to ICD-O-3 site.  Incidence rates were age-adjusted (ASR) to the European standard population by the direct method and 95% Confidence intervals (95% CI) calculated using STATA SE11.0. A literature review was conducted to ascertain the percentage attributable to HPV for each cancer type. Over 300 articles were reviewed and graded by relevance, sample size, and date. RESULTS: ASRs for HPV-related cancers were: vagina/vulval cancers: 0.33(95% CI 0.3-0.4) and 1.4(95% CI: 1.3-1.4) per 100,000 females. Penile cancer: 0.8(95% CI: 0.7-0.8) per 100,000 males. Anal  cancers: 10.8(95% CI:10.7-11.1) males and 6.0(95% CI:5.8-6.0) females per 100,000. Base of tongue and lingual tonsil: 0.06(95% CI:0.06-0.07) males and 0.02(95% CI:0.01-0.02) females per 100,000; tonsil: 0.11(95% CI:0.10-0.12) males and 0.03(95% CI:0.03-0.04) females per 100,000;oropharynx: 0.05(95% CI:0.05-0.06) males and 0.02(95% CI:0.01-0.02) females per 100,000. Estimates reported in literature for percentage of HPV-attributable cases ranged from 70-100% for cervical, 27-76% vulval, 70-90% vaginal, 40-54% penile, 76-90% anal, and 11-72% for HPV-associated H+N cancers. The most commonly reported strains were HPV 16, 18, 31, and 33. CONCLUSIONS: The incidence of HPV-related cancers represents a significant burden. Recent incidence estimates are similar to 2002 estimates, apart from an increase in anal cancers. Estimates of the HPV-attributable percentage for each cancer and projected prevalence will be used to assess the impact of implementing a quadrivalent HPV vaccination programme in England.