OBJECTIVES: The objective is to identify published studies reporting utility values or preferences for health states elicited from the Spanish population with the long-term purpose of maintaining an updated database of utilities that can be of help for the research community. METHODS: A systematic review was conducted to identify studies that elicited utilities by means of questionnaires validated in Spain (EQ-5D, SF-6D, etc.) or accepted techniques (time trade-off, standard gamble, etc.), from healthy or non-healthy populations. We initially focused in cancer, diabetes and heart diseases. An electronic search was developed and run in MEDLINE, EMBASE, PsycINFO, NHS CRD, Cochrane Central Register of Controlled Trials, CINAHL and Spanish databases. Original utility sources were identified from clinical trials, observational studies, systematic reviews and economic evaluations. Studies that fulfilled the inclusion criteria were reviewed and data-extracted. The synthesis was narrative. RESULTS: After discarding duplicates, 1528 citations were screened, and 833 full papers were retrieved for consideration. Eight out of 145 studies were included, which focused in either diabetes or heart disease. From these, 21 utility values were identified and included in the database. Most of the excluded studies used SF-36 or EQ-5D, but only for descriptive purposes, and did not calculate the utility index. CONCLUSIONS: Few studies were available providing utilities elicited from the Spanish population for prevalent diseases such as diabetes or heart disease. As next steps, other diseases will be explored, searches will be conducted in other databases, authors and experts will be contacted to identify additional, relevant information, and included studies will be quality-assessed. This ongoing review and the database of Spanish utilities will be useful for researchers developing economic evaluations or requiring information on quality of life derived from the Spanish population. The project will also allow us to identify data gaps for which further research is needed.