OBJECTIVES: This study aims to perform a systematic expert evaluation of the measurement properties of specific health-related quality of life instruments for prostate cancer. METHODS: We conducted a systematic literature search to identify articles about specific health-related quality of life instruments developed for prostate cancer. Secondly, titles and abstracts were reviewed independently by two experts and, in case of discrepancies, by a third expert to filter the information. Thirdly, for every instrument identified, two experts reviewed the articles about measurement properties and applied the EMPRO tool (Evaluating the Measurement of Patient-Reported Outcomes), which was specifically designed for a standardized evaluation of measurement properties of PRO instruments regarding: conceptual and measurement model, reliability, validity and responsiveness among other. Scores are transformed to a scale from 0 to 100. RESULTS: Ten specific questionnaires were indentified with great variability regarding available information on measurement properties (between 2 and 13 articles): DALE questionnaire (2), ESCAP_CDV (2), TALCOTT questionnaire (2), PCQoL (3), EORTC QLQ PR-25 (3), PORPUS (3), PROSQOLI (4), EPIC (7), FACT-P (11) and UCLA-PCI (13). Only 5 out of 10 questionnaires provided full information regarding their measurement properties. Regarding their conceptual and measurement model, EPIC demonstrated the highest score (>90), followed by UCLA-PCI, PROSQOLI, Talcott questionnaire, PCQoL, EORTC PR25, and PORPUS (>50). Only three questionnaires presented high reliability scores (EPIC and PCQoL >80, UCLA-PCI >50). UCLA-PCI showed the highest scores for validity (>80), followed by PORPUS and PCQoL (>70), PROSQOLI and EPIC (>50). Highest responsiveness scores were observed for PCQoL (100), EPIC and PORPUS (>80), and PROSQOLI (>70). CONCLUSIONS: In this systematic evaluation, only 2 out of 10 questionnaires provided information supporting their conceptual and measurement model, as well as good reliability, validity and responsiveness: EPIC and PCQoL. All instruments have a psychometric design except PORPUS, which was designed to perform cost-utility analysis.